At AstraZeneca 肿瘤学, our overarching ambition is to one day eliminate 癌症 as a cause of death. 在澳门葡京赌博游戏努力实现这一目标的同时，澳门葡京赌博游戏的肿瘤R&D战略有三个核心组成部分:
通过持续的创新，澳门葡京赌博游戏已经建立了行业中最多样化的产品组合之一，并将继续扩大. We are balancing our focus on our industry-leading pipeline with the active life-cycle management of our existing medicines; expanding indications, to deliver to those 癌症 patients with the greatest unmet need.
此外, collaborations and business development opportunities 这是澳门葡京赌博游戏加强投资组合和为未来成功奠定基础的方法的一个组成部分吗. Learn more about our partnerships in oncology R&D.
多角度攻击癌症
We approach the development of transformational medicines in two distinct ways:
- 通过激活免疫系统来增强身体的自然防御能力，从而减缓癌细胞的生长, destroy the cells or to stop them from spreading.
- by focusing on mechanisms that kill 癌症 cells directly.
Combining the two approaches may combat multiple tumour escape mechanisms, potentially allowing for greater anti-tumour activity than with one pathway alone. 像这样, our portfolio spans multiple scientific platforms, 通过不同的方式和机制直接杀死癌细胞或激活免疫系统对抗癌症:
Figure 1: Our scientific platforms to attack 癌症 from multiple angles
- 抗体药物偶联物(ADC): 的se targeted medicines deliver chemotherapy agents to 癌症 cells with monoclonal antibodies, joined via a chemical linker to cytotoxic drugs. 这种高度靶向和细胞特异性的机制有可能减少那些正在接受药物治疗的人的副作用. 1
- Radioconjugates: This approach delivers the radiation therapy to tumour cells, 使癌细胞能够以比传统的外部光束辐射更有针对性的方式被摧毁, offering more tailored treatments for patients.
- DNA损伤反应(DDR): DNA损伤是一个关键因素 tumour progression and most 癌症s have a greater dependency on this process. DDR inhibitors block specific components of the DNA damage response pathways in 癌症 cells, causing 癌症 cell death while leaving healthy cells intact. 2
- 肿瘤驱动因素和耐药性: 澳门葡京赌博游戏正在开发直接针对特定 突变和阻断导致癌细胞增殖的 耐药 机制的疗法, 目标是通过靶向生物途径延长生存期，随着癌症的发展与之抗争.
- 实验胚胎学: 失调的 表观遗传过程 can result in disease initiation and is a hallmark of 癌症. By studying how these epigenetic malfunctions lead to 癌症, we can develop therapies to target those changes.3,4
- Immuno-oncology (IO): 澳门葡京赌博游戏正在开发下一代 IO 疗法 使免疫系统更有效地 识别和杀死癌细胞，并 克服癌症在进化过程中经常产生的免疫抑制机制. 澳门葡京赌博游戏专注于IO疗法的新组合，并设计双特异性抗体，同时针对同一细胞上的不同免疫检查点.
- 免疫衔接器: 人们越来越感兴趣的领域是 t细胞衔接器 which redirect the immune system's T-cells to recognise and kill 癌症 cells, thereby amplifying a patient’s own anti-癌症 immune response.5
- 细胞疗法: 澳门葡京赌博游戏正在建立下一代细胞疗法的管道，旨在克服目前广泛采用细胞疗法治疗实体和血液肿瘤的障碍, such as challenges in scalability and accessibility. 澳门葡京赌博游戏收购了Neogene therapeutics, we are expanding into T-cell receptor therapies (TCR-T), unlocking new space in 癌症 biology by targeting intracellular targets.6
Real potential is in combinations of 癌症 therapies for deeper, 更持久的反应
We believe that real potential is in the combination of treatments, 从多个角度攻击癌细胞. 澳门葡京赌博游戏的投资组合的广度和深度使澳门葡京赌博游戏能够尝试许多这些组合，以实现更持久, 随着澳门葡京赌博游戏努力实现改变癌症结果和增加治愈机会的目标，澳门葡京赌博游戏将做出更深入的回应.
澳门葡京赌博游戏正在努力实现一个未来，即传统的化疗和放疗被adc的靶向组合所取代, 分子靶向治疗, 和免疫疗法.
例如, 将直接杀死癌细胞的adc与驱动患者自身免疫反应并支持组织微环境以根除肿瘤的免疫疗法相结合, may help drive stronger and more durable patient responses. 澳门葡京赌博游戏还在探索通过将adc与DDR抑制剂联合使用来最大化DNA损伤诱导的癌细胞死亡的潜力.
更早、更聪明地治疗癌症
Figure 2: Finding 癌症 earlier through screening and diagnostics like 循环肿瘤DNA (ctDNA)
以变革性技术领先
数据与人工智能
只要掌握了正确的数据, we can transform 癌症 drug discovery and development to get new treatments to patients faster. 数据与人工智能 嵌入澳门葡京赌博游戏所有的R&D活动, from identification of new targets for novel 癌症 medicines, 预测要制造哪些分子, 更好地预测临床成功, 通知, 加快临床试验招募. 数据与人工智能 is enabling us to harness new technology, 自动化流程和 推动科学的边界，加速创新和提供改变生活的药物.
计算病理学
计算病理学 机器学习和数字成像与传统病理技术的整合是否会成为下一代诊断技术. 数据科学和计算技术的进步使澳门葡京赌博游戏能够将免疫组织化学染色的癌症组织图像数据与基因组数据相结合, 放射学, 临床, 还有其他数据, applying deep learning algorithms to gain novel insights.
Quantitative Continuous Scoring (QCS) is our novel, 全自动计算病理学解决方案，不仅寻找生物标志物的存在或不存在，还量化染色强度及其在亚细胞区室中的位置. 现在, we’re pioneering the use of QCS within our 临床 trial portfolio, with regulatory approval as a first-in-class AI-driven diagnostic as a future goal.
数字医疗
的 数字的能力 澳门葡京赌博游戏在R上嵌入&D are essential to creating a seamless connectivity between people and data. 澳门葡京赌博游戏的目标是重新构想医疗保健-改变患者的医疗保健旅程，以改善早期诊断, more precision treatments and proactive digital monitoring for better outcomes, 数字化驱动, 纵向数据与人工智能, 通过最近推出的Evinova, our global health-tech business we’re even closer to this ambition.
澳门葡京赌博游戏还在继续研究, 创建和提供数字医疗解决方案, 通过Evinova, 都是有科学依据的, evidence-led, 人类的经验驱动. Deliberately designed so that everyone can reach better health outcomes together.
肿瘤学的未来&D
It is the combination of all these elements that we believe sets us up for future success. 通过结合这些创新, we will hopefully transform outcomes and survival for 癌症 patients.
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参考文献
1. 彼得斯C，布朗S. Antibody-drug conjugates as novel anti-癌症 chemotherapeutics. Biosci代表. 2015;35(4):e00225.
2. Alhmoud JF, Woolley JF, Al Moustafa AE, Malki MI. 癌症中的DNA损伤/修复管理. 癌症(巴塞尔). 2020;12(4):1050.
3. 温赖特EN，斯基迪迪，P. Epigenetics and 癌症 stem cells: Unleashing, hijacking, and restricting cellular plasticity. 趋势癌症. 2017;3(5): 372–386.
4. 李建军，李建军，李建军. Targeting chromatic remodeling for 癌症 therapy. 当前Mol药物. 2019;12(3):215-229.
5. Huehls AM, Coupet TA, Sentman CL. Bispecific t细胞衔接器 for 癌症 immunotherapy. 免疫细胞生物学. 2015;93(3):290-296.
6. 国家癌症研究所. CAR T Cells: Engineering patients’ immune cells to treat their 癌症s. 网上: http://www.cancer.gov/about-cancer/treatment/research/car-t-cells. 2024年4月发布.
7. GRAIL宣布与澳门葡京网赌游戏达成战略合作，开发伴随诊断测试以治疗早期癌症. 新闻稿:2022年6月2日. 可以在 http://grail.com/press-releases/grail-announces-strategic-collaboration-with-astrazeneca-to-develop-companion-diagnostic-tests-to-enable-the-treatment-of-early-stage-cancer/. 2024年4月发布.
Veeva ID: Z4-62243
筹备日期:2024年4月